Atosiban acetate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

阿托西班是催产素和加压素激素的抑制剂。它被用作静脉注射药物，作为分娩抑制剂（宫缩抑制剂）以阻止早产。阿托西班抑制催产素介导的肌醇三磷酸从子宫肌细胞膜的释放。

Atosiban is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Atosiban inhibits the oxytocin-mediated release of inositol trisphosphate from the myometrial cell membrane. As a result there is reduced release of intracellular stored calcium from the sarcoplasmic reticulum of myometrial cells and reduced influx of Ca2+ from the extracellular space through voltage gated channels. In addition atosiban suppresses oxytocin-mediated release of PGE and PGF from the decidua. In human pre-term labor atosiban at the recommended dosage antagonizes uterine contractions and induces uterine quiescence. The onset of uterus relaxation following atosiban is rapid uterine contractions being significantly reduced within 10 minutes to achieve stable uterine quiescence.(In Vitro):Atosiban inhibits the oxytocin-mediated release of IP3 from the myometrial cell membrane. There is reduced release of intracellular, stored calcium from the sacroplasmic reticulum of myometrial cells, and reduced influx of Ca2+ from the extracellular space through voltage gated channels. In addition, Atosiban suppresses oxytocin-mediated release of PGE and PGF from the decidua.(In Vivo):The posterior pituitary hormones, oxytocin and arginine vasopressin, differ in structure by only two amino acids, and Atosiban influences physiological effects of arginine vasopressin on the feto-maternal cardiovascular and renal systems. In late-gestation sheep, the administration of Atosiban for 1 hour fails to induce fetomaternal cardiovascular changes. Atosiban blocks the activation of oxytocin-receptor-expressing neurons in the parabrachial nucleus of mice.

Atosiban inhibits the oxytocin-mediated release of IP3 from the myometrial cell membrane. There is reduced release of intracellular, stored calcium from the sacroplasmic reticulum of myometrial cells, and reduced influx of Ca2+ from the extracellular space through voltage gated channels. In addition, Atosiban suppresses oxytocin-mediated release of PGE and PGF from the decidua.

The posterior pituitary hormones, oxytocin and arginine vasopressin, differ in structure by only two amino acids, and Atosiban influences physiological effects of arginine vasopressin on the feto-maternal cardiovascular and renal systems. In late-gestation sheep, the administration of Atosiban for 1 hour fails to induce fetomaternal cardiovascular changes.Atosiban blocks the activation of oxytocin-receptor-expressing neurons in the parabrachial nucleus of mice.

RW22164 | RWJ22164

Others

Other Targets

Others

Others

Preterm labour

914453-95-5

1054.24

C45H71N11O14S2

>98% (HPLC)

DMSO:10 mM

CC(O)=O.CCOc1ccc(C[C@H]2NC(=O)CCSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC2=O)[C@@H](C)CC)[C@@H](C)O)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)cc1

——

(-20℃)

With Ice Pack

≥ 2 years